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Subdue the cytokine storm
in primary HLH
Target interferon gamma (IFNγ) with Gamifant, the first and only FDA-approved treatment for
primary hemophagocytic lymphohistiocytosis (HLH) in patients with refractory, recurrent, or progressive
disease or intolerance to conventional therapy.1,2
Gamifant binds to soluble and receptor-bound forms of IFNγ. Binding to IFNγ neutralizes
its activity, blocking its intracellular signaling to inhibit macrophage activation and the
downstream release of proinflammatory cytokines.1,5-7
Depending on patient response, Gamifant can be incrementally titrated upward or downward.
Similarly, the concomitant dose of dexamethasone may be tapered from the original starting dose
according to the judgment of the treating physician.1
Gamifant yielded a 63% overall response rate (ORR) in patients
with refractory, recurrent,or progressive disease or who were intolerant of conventional
treatment. Seventy percent of patients proceeded to transplant.1